No, the motherboard chipset will not support the newer technology. While it is true that MBR disks cannot be larger than 2TB, this does not preclude you from using a larger disk as a boot disk. You simply have to partition the drive to make the first (boot) partition 2TB or less. You can then format and install the OS to that partition. You just can't leave the full 4TB as a single drive letter, and most users wouldn't do that anyway.
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No, the motherboard chipset will not support the newer technology. While it is true that MBR disks cannot be larger than 2TB, this does not preclude you from using a larger disk as a boot disk. You simply have to partition the drive to make the first (boot) partition 2TB or less. You can then format and install the OS to that partition. You just can't leave the full 4TB as a single drive letter, and most users wouldn't do that anyway.