This is the info from the Lowrance website Begin with the iWAY 250C turned off, not just on stand-by. Stand-by is the default setting for the unit when powering down. Change the settings in the interface menu to power off instead of defaulting to stand-by when the power button is pressed. Connect the iWAY 250C to an available PC port. With the PC turned on and operating, turn the iWAY 250C on. The PC should make a sound recognizing a USB connection. If there is no audible sound, try another USB port on your PC. If there is a tone of recognition and the iWAY 250C is not displayed as a separate drive in My Computer, there may be a drive conflict. Change the drive letter of the iWAY 250C. Click here if you have a drive conflict with Windows 95, 98, or ME.
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This is the info from the Lowrance website
Begin with the iWAY 250C turned off, not just on stand-by. Stand-by is the default setting for the unit when powering down. Change the settings in the interface menu to power off instead of defaulting to stand-by when the power button is pressed. Connect the iWAY 250C to an available PC port. With the PC turned on and operating, turn the iWAY 250C on. The PC should make a sound recognizing a USB connection. If there is no audible sound, try another USB port on your PC. If there is a tone of recognition and the iWAY 250C is not displayed as a separate drive in My Computer, there may be a drive conflict. Change the drive letter of the iWAY 250C. Click here if you have a drive conflict with Windows 95, 98, or ME.