Try dkelly2671's suggestions first to ensure that you don't have an issue with your USB connection or current software installation. Also, make sure that your USB cable is ok (use another one, or if you have a digital camera, try downloading some pictures to your computer - they generally use the same kind of cable). If you still are not getting anywhere, you can try putting the remote in "Safe Mode" and doing a Firmware Update. To do this, launch the Logitech Remote software on your computer and click on "Downloads" (on the top menu bar). Then, take the battery out of your remote and at the same time you connect the USB cable to your remote (it should be already connected on the computer end)press and hold down the Off button at the top of the remote. This will put the remote in "safe mode". Continue to hold down the Off button until you see the message "safe mode requested" on the remote's screen and the screen starts blinking. Once you see this, you can release the Off button. Now, go back to your computer and click on "Firmware". If the software is able to communicate with the remote, an update to the remote's firmware should be executed. Good luck!