That depends on what you want the picture to say to the viewer. If you want a deep depth of field, set a small aperture (large f/number). If you want a narrow depth of field, set a large aperture (small f/number). If you want to freeze motion, use a fast shutter speed. If you want to blur motion, use a slow shutter speed. There's no such thing as a best setting for all pictures, or there would be no need for the other settings.
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That depends on what you want the picture to say to the viewer. If you want a deep depth of field, set a small aperture (large f/number). If you want a narrow depth of field, set a large aperture (small f/number). If you want to freeze motion, use a fast shutter speed. If you want to blur motion, use a slow shutter speed. There's no such thing as a best setting for all pictures, or there would be no need for the other settings.